Bupleurum Extract

Introduction of Bupleurum Extract:

Bupleurum is propagated from seed in spring or by root division in autumn and requires well-drained soil and plenty of sun. The root is unearthed in spring and autumn. Distribution mainly in Chinese provinces such as Hebei, Liaoning, Jilin, Heilongjiang, Henan and Shaanxi.

Bupleurum extract is a fine brown powder extracted from the dry root or whole plant of Bupleurum chinense DC. or B. scorzoner-ifolium Willd. of the Umbelliferae plant. Common medicinal Bupleurum can be divided into North Bupleurum and South Bupleurum, which are distributed in Northeast, North, Northwest, Central and East China provinces (Chemicalbook). The main active ingredient of Bupleurum bupleuri extract is total saponin, which has the effect of reconciling exterior and interior, soothing the liver and relieving depression. Pharmacological studies have shown that it has antipyretic, analgesic, sedative, anticonvulsant, hepatoprotective, anti-inflammatory, anti-ulcer, Improve immune function and so on. As early as 1987, relevant medical research departments in my country used tablets made of flavonoid alcohols from Bupleurum stem and leaf extracts to treat children with pneumonia, and the effect was remarkable.

Specification of Bupleurum Extract

Benefits of Bupleurum Extract :

1. Antipyretic effect

The active ingredient of Bupleurum bupleuri extract (eugenol, caproic acid, r-undecanolide and p-methoxybenzodione) has the effect of inhibiting and killing pathogens, so it is effective against typhoid and paratyphoid vaccines. , Escherichia coli liquid, fermented milk, yeast, etc. have obvious antipyretic effect; and can lower the normal body temperature of animals.

2. Anti-inflammatory effect

Saikosaponin has a significant inhibitory effect on various inflammatory processes including inflammatory exudation, increased capillary permeability, release of inflammatory mediators, migration of leukocytes, hyperplasia of connective tissue and various allergic inflammations.

3. Antiviral effect

Bupleurum extract has strong antiviral activity, can significantly inhibit influenza virus in chicken embryos, reduce the increase of lung index caused by mouse pneumonia virus, prevent exudative lesions of lung tissue, and reduce mouse mortality caused by pneumovirus .

4. Liver protection

The hepatoprotective activity of saikosaponin is mainly manifested in the following aspects:
①Reduce the activity of cytochrome P450, protect liver cell necrosis, and promote liver cell regeneration;
②Stimulate the pituitary adrenal cortex system to increase the secretion of endogenous glucocorticoid;
③Reduce the coenzyme cytochrome C reductase activity of dehydrogenase, and reduce the reaction of hormone-like side effects;
④ Activate giant cells to promote the production of antibodies and interferons;
⑤ Promote protein synthesis, increase liver glycogen, reduce lipid peroxide, and promote liver cell regeneration;
⑥Enhance the activity of NK cells and LAK. Saikosaponin also inhibits cholinesterase, prevents acetylcholine from being hydrolyzed by cholinesterase, and then regulates the functions of the digestive system and nervous system, thereby treating liver stagnation syndrome and playing the role of soothing the liver and relieving stagnation.

5. Anti-tumor effect

Bupleurum extract can inhibit mitochondrial metabolic activity and cell proliferation of human liver cancer SMMC7721 cells. It has obvious inhibitory effect on mouse S180 solid tumor. Saikosaponin also has anti-tumor cell molecular adhesion, interferes with DNA synthesis and protein metabolism in the S phase of tumor cells, inhibits cell proliferation, induces cell apoptosis, etc. It also has preventive and therapeutic effects on leukemia, a malignant tumor of the hematopoietic system.

6. Blood lipid lowering effect

Saikosaponin can significantly reduce the experimental increase of serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol in mice, and inhibit the formation of experimental hyperlipidemia in mice, so it can effectively prevent and treat atherosclerosis.

7. Anticonvulsant effect

The reasonable compatibility of saikosaponin and volatile oil has a strong anticonvulsant effect, and it has obvious inhibitory effect on the cerebral cortex discharge and the synaptic transmission process of the central nervous system in the epilepsy model, that is, the Bupleurum extract has a significant inhibitory effect on epilepsy .

The above information is for reference only