:<\/b><\/strong><\/h2>\n1. Antipyretic effect<\/h3>\n
The active ingredient of Bupleurum bupleuri extract (eugenol, caproic acid, r-undecanolide and p-methoxybenzodione) has the effect of inhibiting and killing pathogens, so it is effective against typhoid and paratyphoid vaccines. , Escherichia coli liquid, fermented milk, yeast, etc. have obvious antipyretic effect; and can lower the normal body temperature of animals.<\/p>\n
2. Anti-inflammatory effect<\/h3>\n
Saikosaponin has a significant inhibitory effect on various inflammatory processes including inflammatory exudation, increased capillary permeability, release of inflammatory mediators, migration of leukocytes, hyperplasia of connective tissue and various allergic inflammations.<\/p>\n
3. Antiviral effect<\/h3>\n
Bupleurum extract has strong antiviral activity, can significantly inhibit influenza virus in chicken embryos, reduce the increase of lung index caused by mouse pneumonia virus, prevent exudative lesions of lung tissue, and reduce mouse mortality caused by pneumovirus .<\/p>\n
4. Liver protection<\/h3>\n
The hepatoprotective activity of saikosaponin is mainly manifested in the following aspects:
\n\u2460Reduce the activity of cytochrome P450, protect liver cell necrosis, and promote liver cell regeneration;
\n\u2461Stimulate the pituitary adrenal cortex system to increase the secretion of endogenous glucocorticoid;
\n\u2462Reduce the coenzyme cytochrome C reductase activity of dehydrogenase, and reduce the reaction of hormone-like side effects;
\n\u2463 Activate giant cells to promote the production of antibodies and interferons;
\n\u2464 Promote protein synthesis, increase liver glycogen, reduce lipid peroxide, and promote liver cell regeneration;
\n\u2465Enhance the activity of NK cells and LAK. Saikosaponin also inhibits cholinesterase, prevents acetylcholine from being hydrolyzed by cholinesterase, and then regulates the functions of the digestive system and nervous system, thereby treating liver stagnation syndrome and playing the role of soothing the liver and relieving stagnation.<\/p>\n
5. Anti-tumor effect<\/h3>\n
Bupleurum extract can inhibit mitochondrial metabolic activity and cell proliferation of human liver cancer SMMC7721 cells. It has obvious inhibitory effect on mouse S180 solid tumor. Saikosaponin also has anti-tumor cell molecular adhesion, interferes with DNA synthesis and protein metabolism in the S phase of tumor cells, inhibits cell proliferation, induces cell apoptosis, etc. It also has preventive and therapeutic effects on leukemia, a malignant tumor of the hematopoietic system.<\/p>\n
6. Blood lipid lowering effect<\/h3>\n
Saikosaponin can significantly reduce the experimental increase of serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol in mice, and inhibit the formation of experimental hyperlipidemia in mice, so it can effectively prevent and treat atherosclerosis.<\/p>\n
7. Anticonvulsant effect<\/h3>\n
The reasonable compatibility of saikosaponin and volatile oil has a strong anticonvulsant effect, and it has obvious inhibitory effect on the cerebral cortex discharge and the synaptic transmission process of the central nervous system in the epilepsy model, that is, the Bupleurum extract has a significant inhibitory effect on epilepsy .<\/p>\n
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